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Cincinnati at Kansas BIG 12 CFB Pick: 9-27-25

Cincinnati vs. Kansas CFB Pick ATS

Cincinnati Bearcats at Kansas Jayhawks: Week 5 Big 12 Showdown

Game Details: Saturday, September 27, 2025 | Lawrence, Kansas
Spread: Kansas -5.5 | Total: 55.5 (Betonline)

The Big 12 conference slate continues this Saturday as the Cincinnati Bearcats travel to Lawrence to face the Kansas Jayhawks in a matchup between two programs off to a 2-1 start.

Tale of Two Seasons

Both teams enter this contest with 2-1 records, but the paths taken have been markedly different. The Bearcats’ signature moment came in a narrow 20-17 road loss at Nebraska, showing they can compete with quality opponents. However, a concerning -2 turnover margin suggests ball security issues that could prove costly against better competition.

Kansas, meanwhile, suffered a home setback against Missouri before bouncing back with convincing wins over Wagner and West Virginia. The Jayhawks currently sit at +3 in turnover margin, a critical advantage that often determines close games. Under the leadership of quarterback Jalon Daniels, Kansas has shown the ability to protect the football while generating takeaways on defense.

Offensive Efficiency: Kansas Holds the Edge

The numbers tell a story about offensive efficiency. Kansas ranks 4th nationally in offensive yards per point at an impressive 10.1, demonstrating exceptional red zone efficiency and explosive play capability. Cincinnati’s 13.9 yards per point is solid, but falls well short of the Jayhawks’ elite production.

Defensively, both teams have performed well when limiting opponent scoring. Kansas posts a respectable 19.2 defensive yards per point (16th nationally), while Cincinnati checks in at 18.1. These numbers suggest both defenses can make crucial stops when needed.

Ground Game Battle

The Bearcats do hold one significant advantage: rushing efficiency differential. Cincinnati boasts a +2.2 yards per rush attempt differential compared to Kansas’ +1.1 mark. This ground game superiority could be crucial for controlling clock and keeping Daniels and the Kansas offense on the sideline.

The Schedule Context

It’s important to acknowledge that early-season statistics come with caveats. Both programs have faced relatively weak strength of schedule to this point, with wins coming largely against inferior opponents. The true test of these teams’ capabilities is still unfolding as conference play intensifies.

Historical Trends and Betting Considerations

Kansas enters this matchup as a 5.5-point home favorite in most markets. The Jayhawks have demonstrated they can deliver in front of their home crowd, and the combination of offensive efficiency, turnover margin advantage, and home-field environment creates a compelling case for Kansas covering the spread.

Cincinnati will need to lean on their ground game advantage and shore up ball security to keep this competitive. The Bearcats have shown they can hang with quality opponents, as evidenced by their narrow loss at Nebraska, but overcoming a five-point deficit on the road against an efficient Kansas offense presents a significant challenge.

The Bottom Line

While Cincinnati brings a physical rushing attack and defensive competence to Lawrence, the statistical profile favors the home team.

Expect Jalon Daniels to orchestrate scoring drives efficiently, the Kansas defense to generate a crucial turnover or two, and the Jayhawks to pull away in the second half.

Pick: Kansas -5.5

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