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| THURSDAY, DECEMBER 16, 2021 | |||
| 1 CHIEFS | 5:20 PM | 2 CHARGERS* | +3 |
| SATURDAY, DECEMBER 18, 2021 | |||
| 3 RAIDERS | 1:30 PM | 4 BROWNS* | +1.5 |
| 5 COLTS* | 5:20 PM | 6 PATRIOTS | +2.5 |
| SUNDAY, DECEMBER 19, 2021 | |||
| 7 EAGLES* | 10:00 AM | 8 WASHINGTON | +7 |
| 9 BILLS* | 10:00 AM | 10 PANTHERS | +10.5 |
| 11 DOLPHINS* | 10:00 AM | 12 JETS | +10 |
| 13 COWBOYS | 10:00 AM | 14 GIANTS* | +11 |
| 15 PACKERS | 1:25 PM | 16 RAVENS* | +5.5 |
| 17 TITANS | 10:00 AM | 18 STEELERS* | +1.5 |
| 19 JAGUARS* | 10:00 AM | 20 TEXANS | +3.5 |
| 21 CARDINALS | 10:00 AM | 22 LIONS* | +13 |
| 23 49ERS* | 1:05 PM | 24 FALCONS | +9 |
| 25 BRONCOS* | 1:05 PM | 26 BENGALS | +2.5 |
| 27 RAMS* | 1:25 PM | 28 SEAHAWKS | +4.5 |
| 29 BUCCANEERS* | 5:20 PM | 30 SAINTS | +11 |
| MONDAY, DECEMBER 20, 2021 | |||
| 31 VIKINGS | 5:15 PM | 32 BEARS* | +4 |
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