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| THURSDAY, DECEMBER 23, 2021 | |||
| 1 49ERS | 5:20 PM | 2 TITANS* | 3 |
| SATURDAY, DECEMBER 25, 2021 | |||
| 3 PACKERS* | 1:30 PM | 4 BROWNS | 7.5 |
| 5 CARDINALS* | 5:20 PM | 6 COLTS | 1 |
| SUNDAY, DECEMBER 26, 2021 | |||
| 7 BUCCANEERS | 10:00 AM | 8 PANTHERS* | 10 |
| 9 EAGLES* | 10:00 AM | 10 GIANTS | 9.5 |
| 11 CHARGERS | 10:00 AM | 12 TEXANS* | 10 |
| 13 FALCONS* | 10:00 AM | 14 LIONS | 5.5 |
| 15 BENGALS* | 10:00 AM | 16 RAVENS | 2.5 |
| 17 RAMS | 10:00 AM | 18 VIKINGS* | 3 |
| 19 JAGUARS | 10:00 AM | 20 JETS* | PK |
| 21 PATRIOTS* | 10:00 AM | 22 BILLS | 2.5 |
| 23 SEAHAWKS* | 1:05 PM | 24 BEARS | 6.5 |
| 25 CHIEFS* | 1:25 PM | 26 STEELERS | 7.5 |
| 27 BRONCOS | 1:25 PM | 28 RAIDERS* | PK |
| 29 COWBOYS* | 5:20 PM | 30 WASHINGTON | 11 |
| MONDAY, DECEMBER 27, 2021 | |||
| 31 SAINTS* | 5:15 PM | 32 DOLPHINS | 3 |