Rams at Titans Week 2 NFL Betting Preview: Road Warriors Ready to Cash in Nashville

Game Details: Los Angeles Rams at Tennessee Titans
Date: Sunday, September 14, 2025
Time: 1:00 PM ET
Venue: Nissan Stadium, Nashville, TN
TV: CBS

Current Odds at MyBookie:

• Spread: Rams -5.5
• Total: 42 points
• Moneyline: Rams -245, Titans +200

Tale of Two Week 1s Sets the Stage

The Los Angeles Rams and Tennessee Titans enter Week 2 heading in vastly different directions after their season openers. The Rams showcased their championship DNA with a gritty 14-9 victory over Houston, demonstrating the defensive prowess that could carry them deep into the postseason. Meanwhile, Tennessee’s 20-12 road loss to Denver highlighted the growing pains expected with a rookie signal-caller making his professional debut.

Offensive Firepower vs. Developmental Growing Pains

Matthew Stafford’s veteran leadership proved invaluable in the Rams’ Week 1 victory, completing 21 of 29 passes for 245 yards and a touchdown. The quarterback, now in his 17th NFL season, continues to rank among the league’s elite with over 60,000 career passing yards and 378 touchdown passes.

The receiving corps presents a nightmare matchup for Tennessee’s secondary. Puka Nacua’s explosive Week 1 performance—10 catches for 130 yards—served notice that he’s fully recovered from the injury concerns that plagued his sophomore campaign. Paired with newly acquired Davante Adams, who hauled in four receptions for 51 yards in his Rams debut, this tandem creates mismatches across the field.

Supporting cast members Kyren Williams in the backfield provides additional offensive balance, giving Los Angeles multiple weapons that can exploit defensive weaknesses.

On the opposite sideline, Cam Ward’s professional debut revealed the adjustment period facing the former Miami standout. The top overall draft pick managed just 12 completions on 28 attempts for 112 yards, struggling with accuracy and timing against Denver’s aggressive defense. Six sacks allowed by Tennessee’s offensive line didn’t help Ward find his rhythm in the pocket.

Defensive Advantages Point Toward Los Angeles

The Rams’ defensive unit delivered a statement performance in Week 1, limiting a talented Houston offense to just nine points and 265 total yards. This defensive foundation provides confidence that they can contain a Tennessee offense still finding its identity under new leadership.

Tennessee’s defense showed flashes with four takeaways against Denver, including interceptions from Roger McCreary and Xavier Woods, plus fumble recoveries from Jeffery Simmons and Sebastian Joseph-Day. However, these opportunistic plays masked underlying concerns about consistency and pressure generation.

Historical Context and Situational Edges

Series history favors the Rams with an 8-6 all-time advantage, though Tennessee holds a 2-1 edge in previous meetings at Nissan Stadium. The most recent encounter saw Tennessee prevail 28-16 in 2021, but that Titans team featured different personnel and coaching philosophies.

Los Angeles enters as battle-tested playoff participants coming off a 10-7 season and NFC West title under Sean McVay. The franchise’s championship pedigree and experience in pressure situations contrasts sharply with Tennessee’s rebuilding phase following last season’s league-worst performance.

Betting Analysis: Why the Rams Cover -5.5

Multiple factors align to support backing Los Angeles laying the points in Nashville:

Offensive Ceiling Disparity: The Rams possess proven playmakers capable of explosive performances, while Tennessee’s offense appears limited by quarterback inexperience and offensive line concerns. Ward’s 40.6% completion percentage and six sacks allowed in Week 1 suggest continued struggles against another quality defense.

Defensive Momentum: Los Angeles’ defensive performance against Houston demonstrates their ability to neutralize opposing offenses. Tennessee’s offensive limitations make them vulnerable to a similar fate.

Coaching Experience: McVay’s track record in road games and big moments provides a significant edge over Tennessee’s coaching staff navigating a transition year with a rookie quarterback.

Situational Motivation: Road favorites often perform well when facing teams in obvious rebuilding phases, particularly when the talent gap is substantial.

Total Analysis: Under 42 Offers Strong Value

The under presents compelling value based on several key factors:

Defensive Strength vs. Offensive Limitations: Los Angeles’ defensive capabilities combined with Tennessee’s offensive struggles suggest a low-scoring affair. The Rams held Houston to nine points, while Tennessee managed just 12 against Denver.

Historical Trends Support: The UNDER is 4-1 in the Rams’ last five road regular-season games and 4-1 in Tennessee’s last five regular-season contests. These trends indicate both teams frequently participate in lower-scoring games.

Game Flow Expectations: If Los Angeles establishes an early lead, game script favors a grind-it-out approach that limits total possessions and scoring opportunities.

Red Zone Efficiency Questions: Both offenses showed red zone concerns in Week 1, suggesting field goals rather than touchdowns when drives reach scoring position.

Weather and Venue Considerations

September conditions in Nashville typically favor outdoor football without weather-related complications. Nissan Stadium’s artificial surface should provide consistent footing for both teams, eliminating weather as a significant variable.

Key Injury Situations to Monitor

Los Angeles may be without key offensive linemen Steve Avila and Kevin Dotson, potentially impacting pass protection. However, their offensive weapons provide enough talent to overcome line concerns.

Tennessee faces questions about right tackle J.C. Latham’s hip injury status, which could further compromise pass protection for Ward.

Final Recommendations

Best Bet: Rams -5.5 – The talent disparity and situational advantages strongly favor Los Angeles covering the spread in what should be a comfortable road victory.

Strong Lean: Under 42 – Defensive advantages and offensive limitations on both sides point toward a lower-scoring contest that stays well under the posted total.

The combination of Los Angeles’ proven veterans against Tennessee’s developmental roster creates an ideal betting scenario for backing the road favorite while expecting a defensive struggle that keeps the total low.